APIDRA is used to reduce high blood sugar in adults and children (6 years or older) with diabetes mellitus.
The dosage of APIDRA is individualized and is determined based on your health professional’s advice in accordance with your needs.
APIDRA is given by subcutaneous injection within 15 minutes before a meal or within 20 minutes after starting a meal.
Their are factors that may affect your usual APIDRA dose, which include changes in your diet, activity, or work schedule. Follow your health professional’s instructions carefully. Consult your health professional if you notice your insulin requirements changing.
Other factors that can affect your dose of insulin or your need to do additional blood/urine testing are:
Illness, especially with nausea and vomiting, diarrhea and/or fever, can change how much insulin you need. Even if you are not eating, you will still need insulin. You and your health professional should establish your sick day plan for you to use in case of illness. When you are sick, test your blood/urine frequently and call your health professional as instructed.
If you are planning to have a baby, are pregnant, or are nursing a baby, consult your health professional. Good control of diabetes is especially important for you and your unborn baby. Pregnancy may make managing your diabetes more difficult.
Always discuss your medications you are taking, prescription or “over-the-counter”, with your health professional. To prevent drug interactions, volunteer the names of everything you are taking even before they ask if there have been any changes. Insulin requirements may be increased in the presence of drugs with hyperglycemic activity, such as contraceptives (for example, birth control pills, injections and patches) and hormone replacement therapies, corticosteroids, thyroid replacement therapy, and sympathomimetic agents such as decongestants and diet pills. Insulin requirements may be reduced in the presence of drugs with hypoglycemic activity, such as oral antidiabetic agents, salicylates (for example, aspirin), sulfa antibiotics, blood pressure medications including ACE inhibitors, and certain psychiatric medications including MAO inhibitors or antidepressants and anti-anxiety medications.
Substances including beta-blockers, used for conditions including blood pressure, heart arrhythmias, palpitations and headache, and alcohol may enhance or weaken the blood-glucose-lowering effect of insulins, and signs of hypoglycemia may be reduced or absent.
If your exercise routine changes, discuss with your health professional the possible need to adjust your insulin regimen. Exercise may lower your body’s need for insulin during and for some time after the activity. As for all insulins, the rate of absorption, and consequently the onset and duration of action, may be affected by exercise and other variables.
Consult your health professional concerning possible adjustments in your insulin schedule if you will be traveling across time zones. You may want to take along extra insulin and supplies whenever you travel.
If you have missed a dose of APIDRA or if you have not injected enough insulin, your blood sugar level may become too high (hyperglycemia). Check your blood sugar frequently. Do not take a double dose to make up for a forgotten dose.
If you have injected too much APIDRA, your blood sugar level may become too low (hypoglycemia). Check your blood sugar frequently. In general, to prevent hypoglycemia you must eat more food and monitor your blood sugar.
Hypoglycemia may occur as a result of an excess of insulin relative to food intake, energy expenditure, or both.
In severe cases, coma, seizure and brain disorders may be seen and treated with glucagon (injected in the muscle or subcutaneous tissue) or glucose (injected in the vein).
You should continue checking your blood sugar even if you feel better because hypoglycemia may recur.
In case of drug overdose, contact a health professional, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.